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Clinical use of this clip is expected because it can reduce the rate of postoperative complications and minimize problems associated with diagnostic imaging.The surgical clipThe clip was developed as a collaboration between the Division of Mechanics and Physics of Materials at the Kobe University Graduate School of Engineering and the Division of Hepato-Biliary-Pancreatic Surgery at the Kobe University Graduate School of Medicine. Most surgical clips are currently made of titanium, and as many as 30 to 40 clips may be used during a single surgical procedure. They remain inside the patient’s body after the wounds are healed. Retained clips lead to diminished quality of CT (computed tomography) and MRI (magnetic resonance imaging) images around the wound and may cause complications. The newly developed clip is 5 mm in size and made of a magnesium alloy. The alloy also contains calcium and zinc to improve its microstructure, ensuring fastening ability and formability, qualities required of materials to make clips.The safety and functionality of the clip were evaluated in vivo studies. To evaluate the safety, an implantation study was conducted in a subcutaneous mouse model. Very little gas was produced as the clip dissolved and there was no inflammation of the surrounding tissues after 1 to 12 weeks. These results suggest that the clip is associated with very few adverse effects. Blood testing revealed that levels of magnesium and other substances in the blood were in the normal range after 12 weeks. The volume of the implanted clip was reduced by almost half after 12 weeks. Therefore, the clip is likely to dissolve and exit the body within 1 year.To evaluate its functionality, it was tested in a rat model in which the biliary duct, portal vein, hepatic artery, and hepatic vein were occluded with the clip and a partial liver was removed. The rat had no problems during a monitoring period of 8 weeks, suggesting that the clip functioned properly. Micro CT scanning of the mouse and rat revealed that the quality of images was not degraded and organs can be observed.Professor MUKAI Toshiji (Department of Mechanical Engineering, Graduate School of Engineering), who was involved in developing the clip, expressed his hopes: “We will conduct further in vivo studies and a clinical study within 2 to 3 years. Kobe University works toward the development of new medical devices. We will continue to promote collaboration between the Graduate Schools of Medicine and Engineering.”ResearchersMukai ToshijiProfessorGraduate School of MedicineGraduate School of EngineeringGraduate School of MedicineSHAREMore about these topicsFeatures2024.04.22Medicine, dentistry and pharmacologyA new department for the development of new medical devicesFeatures2022.09.29Medicine, dentistry and pharmacologyMedical engineering collaboration aims for accurate hearing loss diagnosesFeatures2021.11.09Medicine, dentistry and pharmacologyKobe University: A Global Knowledge Base that will Invigorate Future SocietyPress releases2020.06.19Medicine, dentistry and pharmacologyTearExo®: new breast cancer detection method uses tearsページの先頭へ1-1, Rokkodai-cho, Nada-ku, Kobe, 657-8501, JAPANProspective studentsCurrent studentsAlumsCorporate and societyFaculty and staffContactAccessJobsOfficial social media accountsCampus calendarPrivacy policySite policySite map© Kobe University