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Home About Traditions &#038; History Careers at YCU Academics Undergraduate Study School of International Liberal Arts School of Economics and Business Administration School of Science School of Data Science School of Medicine School of Medicine: Medical Course School of Medicine: Nursing Course Graduate Study Graduate School of Urban Social and Cultural Studies Graduate School of International Management Graduate School of Nanobioscience Graduate School of Nanobioscience: Department of Materials System Science Graduate School of Nanobioscience: Department of Life and Environmental System Science Graduate School of Data Science Graduate School of Data Science: Department of Data Science Graduate School of Data Science: Department of Health Data Science Graduate School of Medical Life Science Graduate School of Medicine Graduate School of Medicine: Department of Medicine Graduate School of Medicine: Department of Nursing Non-Degree Programs Exchange Program International Clinical Clerkship Research-Only Career Development Support Admissions Research Advanced Medical Research Center Kihara Institute for Biological Research Life at YCU Kanazawa-Hakkei Campus Life Fukuura Campus Life Living in Yokohama Clubs &#038; Societies Health &#038; Wellness Global International Affairs Office Exchange Program Partner Institutions Global Cooperation Institute for Sustainable Cities (GCI) 日本語 New Study Shows Key Role of Synaptic Plasticity in Modulating Brain Function in Patients with Epilepsy2023-05-17Comparative analyses define differences between BHD-associated renal tumour and sporadic chromophobe renal cell carcinoma2023-05-19 Show all Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy Date: 17 May 23 Researcher(s):Takuya Takahashi The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) contribute to epileptogenesis. Thirty patients with epilepsy and 31 healthy controls are scanned using positron emission tomography with our recently developed radiotracer for AMPARs, [11C]K-2, which measures the density of cell-surface AMPARs. In patients with focal-onset seizures, an increase in AMPAR trafficking augments the amplitude of abnormal gamma activity detected by electroencephalography. In contrast, patients with generalized-onset seizures exhibit a decrease in AMPARs coupled with increased amplitude of abnormal gamma activity. Patients with epilepsy had reduced AMPAR levels compared with healthy controls, and AMPARs are reduced in larger areas of the cortex in patients with generalized-onset seizures compared with those with focal-onset seizures. Thus, epileptic brain function can be regulated by the enhanced trafficking of AMPAR due to Hebbian plasticity with increased simultaneous neuronal firing and compensational downregulation of cell-surface AMPARs by the synaptic scaling.Link to full article   For inquiries regarding this press release Takuya TakahashiProfessor Department of Physiology, Yokohama City University Graduate School of Medicine, 3-9 Fuku-ura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan Search ✕ Latest newsActivity of MEXT Scholarship Alumni After Returning to Their Home Country2024-04-25Intraoperative Integrated Diagnostic System for Malignant Central Nervous System Tumors2023-11-21 Research Research News Advanced Medical Research Center Kihara Institute for Biological Research Researcher Database Global International Affairs Office International Student Support Exchange Program Partner Institutions Global Cooperation Institute for Sustainable Cities (GCI) GCI: Overview GCI: Activities International Academic Consortium for Sustainable Cities (IACSC) Living in Yokohama Admissions 22-2 Seto, Kanazawa-ku, Yokohama, Kanagawa 236-0027 Japan Undergraduate Schools International Liberal Arts Economics and Business Administration Science Data Science Medicine Graduate Schools Urban Social and Cultural Studies International Management Nanobioscience Medical Life Science Medicine  Data Science Admissions Undergraduate Graduate Non-Degree Programs Research Advanced Medical Research Center Kihara Institute for Biological Research Research Database Hospitals Yokohama City University Hospital Yokohama City University Medical Center Life at YCU Campus Life Living in Yokohama Clubs & Societies Health & Wellness Global International Affairs Office Global Cooperation Institute for Sustainable Cities Exchange Programs Partner Institutions NewsActivity of MEXT Scholarship Alumni After Returning to Their Home Country2024-04-25Simplifying the Estimation of Volatile Organic Compounds Emitted From Wildfires2023-10-26Event Report: The 14th IACSC International Symposium/General Assembly2023-10-10 © 2021 Yokohama City University. 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