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  大学ホームページ 図書館ホームページ 運営規程 登録・公開許諾書 パンフレット  更新日：2024/05/22    件数：7,050件     TOP  Language   JapaneseEnglishヘルプ No.1(全1件)     検索画面戻る一覧 Possibility of Multiple Drug-Drug Interactions in Patients Treated with Statins: Analysis of Data from the Japanese Adverse Drug Event Report (JADER) Database and Verification by Animal Experimentsこのページを印刷URL:   ダウンロード  IDJOS-ijms.76139著者：名前根岸, 彰生/大島, 新司/武藤, 香絵/堀井. 徳光/井上, 直子/沼尻, 幸彦/大嶋, 繁/小林, 大介著者：別形式Negishi, Akio / Oshima, Shinji / Mutoh, Mizue / Horii, Norimitsu / Inoue, Naoko / Numajiri, Sachihiko / Ohshima,Shigeru / Kobayashi, Daisuke著者：カナネギシ, アキオ/オオシマ, シンジ/ムトウ, ミズエ/ホリイ, ノリミツ/イノウエ, ナオコ/ヌマジリ, サチヒコ/オオシマ, シゲル/コバヤシ, ダイスケ著者：所属城西大学薬学部薬学科薬剤作用解析学研究室 / 城西大学薬学部薬学科薬剤作用解析学研究室 / 城西大学薬学部薬学科薬局管理学研究室 / 城西大学薬学部薬学科薬局管理学研究室 / 城西大学薬学部薬学科薬局管理学研究室 / 城西大学薬学部薬学科教育支援室 / 城西大学薬学部薬学科薬局管理学研究室 / 城西大学薬学部薬学科薬剤作用解析学研究室著者：所属(別形式）Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Student Learning Assistance Center / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Analytical Pharmaceutics and Informatics著者版フラグpublisher出版地Sydney出版者Ivyspring International Publisher電子ISSN14491907掲載誌名International Journal of Medical Sciences巻19号12刊行年月2022-10開始ページ1816終了ページ1823コンテンツ作成日2022-06-14コンテンツ修正日2022-09-13コンテンツ登録日2022-12-24識別番号：DOIinfo:doi/10.7150/ijms.76139識別番号：DOI（リンク）https://doi.org/10.7150/ijms.76139PubMed番号36313225抄録Adverse drug events due to drug-drug interactions can be prevented by avoiding concomitant use of causative drugs; therefore, it is important to understand drug combinations that cause drug-drug interactions. Although many attempts to identify drug-drug interactions from real-world databases such as spontaneous reporting systems have been performed, little is known about drug-drug interactions caused by three or more drugs in polypharmacy, i.e., multiple drug-drug interactions. Therefore, we attempted to detect multiple drug-drug interactions using decision tree analysis using the Japanese Adverse Drug Event Report (JADER) database, a Japanese spontaneous reporting system. First, we used decision tree analysis to detect drug combinations that increase the risk of rhabdomyolysis in cases registered in the JADER database that used six statins. Next, the risk of three or more drug combinations that significantly increased the risk of rhabdomyolysis was validated with in vivo experiments in rats. The analysis identified a multiple drug-drug interaction signal only for pitavastatin. The reporting rate of rhabdomyolysis for pitavastatin in the JADER database was 0.09, and it increased to 0.16 in combination with allopurinol. Furthermore, the rate was even higher (0.40) in combination with valsartan. Additionally, necrosis of leg muscles was observed in some rats simultaneously treated with these three drugs, and their creatine kinase and myoglobin levels were elevated. The combination of pitavastatin, allopurinol, and valsartan should be treated with caution as a multiple drug-drug interaction. Since multiple drug-drug interactions were detected with decision tree analysis and the increased risk was verified in animal experiments, decision tree analysis is considered to be an effective method for detecting multiple drug-drug interactions.キーワードmultiple drug-drug interaction/decision tree analysis/spontaneous reporting system/statin/rhabdomyolysis/polypharmacy注記This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.言語 eng資源タイプtextジャンル01学術雑誌論文 / Journal Articleフォーマットapplication/pdf権利Copyright © The author(s).このアイテムを表示する：本文(pdf)( 989.3KB) ダウンロード回数： 回このアイテムを表示する：URIhttps://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-ijms.76139URL:G0000284repository_JOS-ijms.76139  var xurl =document.URL; var xrecid = 'G0000284repository_JOS-ijms.76139'; var xReg = new RegExp(/(.*meta.*\/)/); var xmatch = xurl.match(xReg); var urlstr = RegExp.$1; if( xmatch) jQuery('a#infolib_permalink').html( urlstr + xrecid ); detailcont["max"] = '0'; detailcont["detailViewFlg"] = '0'; var xswitchViewButton = jQuery('div#detailContentsSwicher'); xswitchViewButton.show(); var xEditorButton = jQuery('div#detailEditor'); if( xEditorButton.length) { xpanel.xEditorPrime = "JOS-ijms.76139"; xEditorButton.show(); } detailcont["contentsDspMax"] = '5'; detailcont["show"] = 'all'; detailcont["contentsDbId"] = 'G0000284repository'; detailcont["currentContNo"] = '0'; meta.detailSetViewerHeight(); Copyright(C) 2010 Josai University. 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